Subjects with high-normal blood pressure shown to have a higher prevalence of cardiovascular and metabolic risk factors
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High-normal blood pressure has been associated with other cardiovascular risk factors in a few population-based studies. This cross-sectional study compared blood pressure categories with cardiovascular risk factors in a population-based cohort of 1658 adults. Glucose, triglycerides, LDL cholesterol, alanine aminotransferase, gamma-glutamyl transferase values, and diabetes and metabolic syndrome prevalence were significantly higher in subjects with high-normal blood pressure than in those with optimal blood pressure. Multiple regression analyses revealed that adiponectin and total antioxidant status were significantly lower in a healthy lean subgroup. Nitrotyrosine, E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 were higher in subjects with high-normal blood pressure than in those with optimal blood pressure. Thus, subjects with high-normal blood pressure appear to have a higher prevalence of cardiovascular and metabolic risk factors compared to those with optimal blood pressure. Further research is needed to determine whether these prehypertensive subjects would benefit from active blood pressure reduction.
Abstract
