Subjects with prehypertension are at increased risk of diabetes
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Although prehypertension has been shown to be associated with cardiovascular disease and insulin resistance, it is not yet known whether prehypertension is also associated with diabetes incidence risk. For this reason, incident diabetes was examined in 2767 nondiabetic, normotensive adults participating in the San Antonio Heart Study. JNC 7 category defining prehypertension was 120-139/80-89 mmHg. During a median follow-up of 7.8 years, incident diabetes was observed in 12.4% of subjects with prehypertension versus 5.6% of subjects with normal blood pressure. After adjusting for age, gender, and ethnicity, the odds of incident diabetes were 2.21 greater in subjects with prehypertension than in those with normal blood pressure. After further adjustments for BMI, impaired glucose tolerance, insulin resistance, insulin secretion and family history of diabetes, prehypertension was no longer associated with incident diabetes. According to these findings, subjects with prehypertenion are at increased risk of diabetes, which is mainly accounted for by disorders related to the insulin resistance syndrome.
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